Yicheng Guo, PhD

  • Assistant Professor of Medical Sciences ( in Medicine) at CUMC

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Overview

Academic Appointments

  • Assistant Professor of Medical Sciences ( in Medicine) at CUMC

Languages

  • Chinese

Gender

  • Male

Credentials & Experience

Education & Training

  • BA, 2010 Biological Science, Southwest University, China
  • PhD, 2016 Bioinformatics, University of Science and Technology of China
  • Fellowship: 2017 Department of Biochemistry and Molecular Biophysics, Columbia University
  • Fellowship: 2019 Zuckerman Mind Brain Behavior Institute, Columbia University
  • Fellowship: 2021 Aaron Diamond AIDS Research Center (ADARC), Columbia University

Research

Selected Publications

  1. Qian Wang*, Yicheng Guo*, Anthony Bowen*, Ian A Mellis*, Riccardo Valdez, Carmen Gherasim, Aubree Gordon, Lihong Liu, David D Ho. XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants. Cell Host & Microbe. 2024.
  2. Chen Dong*, Yicheng Guo*, Zechuan Chen*, Teng Li*, Juan Ji, Chi Sun, Jing Li, Haixia Cao, Yunfei Xia, Zhonghui Xue, Xixi Gu, Qian Liang, Rui Zhao, Ting Fu, Jiaqiang Ma, Shan Jiang, Chunmei Wu, Qiong Fu, Genkai Guo, Yanfeng Bao, Hua Guo, Junling Yang, Min Xu, Xiaoming Zhang, Zizhang Sheng, Zhifeng Gu. Single-cell profiling of bone marrow B cells uncovers early B cell developmental disorders associated with systemic lupus erythematosus. Arthritis & Rheumatology. 1-15, 2024
  3. Qian Wang*, Yicheng Guo*, Liyuan Liu*, Logan T Schwanz, Zhiteng Li, Manoj S Nair, Jerren Ho, Richard M Zhang, Sho Iketani, Jian Yu, Yiming Huang, Yiming Qu, Riccardo Valdez, Adam S Lauring, Yaoxing Huang, Aubree Gordon, Harris H Wang, Lihong Liu, David D Ho. Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike. Nature. 624, 639–644 (2023)
  4. Lihong Liu*, Ryan G Casner*, Yicheng Guo*, Qian Wang*, Sho Iketani*, Jasper Fuk-Woo Chan*, Jian Yu, Bernadeta Dadonaite, Manoj S Nair, Hiroshi Mohri, Eswar R Reddem, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Kwok-Yung Yuen, Zizhang Sheng, Yaoxing Huang, Jesse D Bloom, Lawrence Shapiro, David D Ho. Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking. Immunity. 56, 2442–2455. 2023
  5. Qian Wang*, Sho Iketani*, Zhiteng Li*, Liyuan Liu*, Yicheng Guo*, Yiming Huang, Anthony D Bowen, Michael Liu, Maple Wang, Jian Yu, Riccardo Valdez, Adam S Lauring, Zizhang Sheng, Harris H Wang, Aubree Gordon, Lihong Liu, David D Ho. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants. Cell. 186, 279–286. 2023
  6. Lihong Liu*, Sho Iketani*, Yicheng Guo*, Eswar R Reddem*, Ryan G Casner*, Manoj S Nair*, Jian Yu*, Jasper F-W Chan*, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C Morano, Candace D Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T Yin, David S Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D Ho. An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses. Science Translational Medicine. 14, (2022).
  7. Qian Wang*, Yicheng Guo*, Sho Iketani, Manoj S. Nair, Zhiteng Li, Hiroshi Mohri, Maple Wang, Jian Yu, Anthony D. Bowen, Jennifer Y. Chang, Jayesh G. Shah, Nadia Nguyen, Zhiwei Chen, Kathrine Meyers, Michael T. Yin, Magdalena E. Sobieszczyk, Zizhang Sheng, Yaoxing Huang, Lihong Liu, David D. Ho. Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5. Nature. 608, 603–608 (2022).
  8. Sho Iketani*, Lihong Liu*, Yicheng Guo*, Liyuan Liu*, Jasper F-W Chan*, Yiming Huang, Maple Wang, Yang Luo, Jian Yu, Hin Chu, Kenn K-H Chik, Terrence T-T Yuen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Kwok-Yung Yuen, Harris H Wang, Zizhang Sheng, David D Ho. Antibody evasion properties of SARS-CoV-2 Omicron sublineages. Nature. 604, 553-556 (2022).
  9. Xiaoqing Zhu*, Yicheng Guo*, Chu Chu*, Dahai Liu*, Kui Duan, Yu Yin, Chenyang Si, Yu Kang, Junjun Yao, Xuewei Du, Junliang Li, Shumei Zhao, Zongyong Ai, Qingyuan Zhu, Weizhi Ji, Yuyu Niu, Tianqing Li. BRN2 as a key gene drives the early primate telencephalon development. Science Advances. 8, (2022).
  10. Lihong Liu*, Sho Iketani*, Yicheng Guo*, Jasper F-W Chan*, Maple Wang*, Liyuan Liu*, Yang Luo, Hin Chu, Yiming Huang, Manoj S Nair, Jian Yu, Kenn K-H Chik, Terrence T-T Yuen, Chaemin Yoon, Kelvin K-W To, Honglin Chen, Michael T Yin, Magdalena E Sobieszczyk, Yaoxing Huang, Harris H Wang, Zizhang Sheng, Kwok-Yung Yuen, David D Ho. Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Nature. 602, 676–681 (2022).
  11. Gabriele Cerutti*, Yicheng Guo*, Tongqing Zhou*, Jason Gorman, Myungjin Lee, Micah Rapp, Eswar R Reddem, Jian Yu, Fabiana Bahna, Jude Bimela, Yaoxing Huang, Phinikoula S Katsamba, Lihong Liu, Manoj S Nair, Reda Rawi, Adam S Olia, Pengfei Wang, Baoshan Zhang, Gwo-Yu Chuang, David D Ho, Zizhang Sheng, Peter D Kwong, Lawrence Shapiro. Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite. Cell Host & Microbe. 29 (2021), pp. 819-833.
  12. Manxue Jia*, Rachel A. Liberatore*, Yicheng Guo*, Kun-Wei Chan*, Ruimin Pan, Hong Lu, Eric Waltari, Eva Mittler, Kartik Chandran, Andrés Finzi, Daniel E Kaufmann, Michael S Seaman, David D Ho, Lawrence Shapiro, Zizhang Sheng, Xiang-Peng Kong, Paul D Bieniasz, Xueling Wu. VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA. Cell Host Microbe (2020), pp. 963-975.
  13. Yicheng Guo, Kevin Chen, Peter D. Kwong, Lawrence Shapiro and Zizhang Sheng. cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence. Frontiers in Immunology 10:2365. (2019).
  14. Chen-Hsiang Shen*, Brandon J. DeKosky*, Yicheng Guo*, Kai Xu*, Ying Gu, Divya Kilam, Sung Hee Ko, Rui Kong, Kevin Liu, Mark K Louder, Li Ou, Baoshan Zhang, Cara W Chao, Martin M Corcoran, Eric Feng, Jesse Huang, Erica Normandin, Sijy O’Dell, Amy Ransier, Reda Rawi, Mallika Sastry, Stephen D Schmidt, Shuishu Wang, Yiran Wang, Gwo-Yu Chuang, Nicole A Doria-Rose, Bob Lin, Tongqing Zhou, Eli A Boritz, Mark Connors, Daniel C Douek, Gunilla B Karlsson Hedestam, Zizhang Sheng, Lawrence Shapiro, John R Mascola, Peter D Kwong. VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage. Cell Host & Microbe, 27 (2020), pp. 531-543.
  15. Wansheng Jiang*, Yicheng Guo*, Kunfeng Yang, Qiong Shi, Junxing Yang. Insights into Body Size Evolution: A Comparative Transcriptome Study on Three Species of Asian Sisoridae Catfish. Int. J. Mol. Sci. 2019, 20(4), 944. (2019).
  16. Yicheng Guo, Lin Zhang, ShaoXing Dai, WenXing Li, JunJuan Zheng, GongHua Li & JingFei Huang. Independent Evolution of Winner Traits without Whole Genome Duplication in Dekkera Yeasts. PLoS ONE 11(5): e0155140. (2016).